HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 779
+	Hs
		412353 FYN_HUMAN (30-507): 0: 586: 59.01		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		411709 LCK_HUMAN (1-509): 0: 661: 100.00		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		411764 LCK_HUMAN (1-509): 0: 661: 100.00		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Hs
		411591 LCK_HUMAN (1-509): 0: 661: 100.00		RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32
+	Hs
		411772 LCK_HUMAN (1-509): 0: 661: 100.00		MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57
+	Hs
		411755 LCK_HUMAN (1-509): 0: 661: 100.00		RHG21_HUMAN (22-662): 1.96e-43: 172: 13.18
+	Hs
		411897 LCK_HUMAN (1-509): 0: 661: 100.00		PKHA6_HUMAN (3-364): 2.39e-40: 162: 26.02
+	Hs
		411861 LCK_HUMAN (1-509): 0: 661: 100.00		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		442825 HCK_HUMAN (1-509): 0: 602: 65.04		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		522965 SRC_HUMAN (20-507): 0: 586: 55.00		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Mm
		403466 SRC_MOUSE (28-507): 0: 583: 57.05		GAB1_MOUSE (52-611): 1.35e-53: 199: 15.45
+	Hs
		433750 LYN_HUMAN (1-509): 0: 582: 62.72		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		442777 HCK_HUMAN (1-509): 0: 602: 65.04		RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32
+	Hs
		411904 LCK_HUMAN (1-509): 0: 661: 100.00		FARP1_HUMAN (6-167): 1.07e-24: 112: 17.96
+	Hs
		522768 SRC_HUMAN (20-507): 0: 586: 55.00		RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32
+	Mm
		763401 FYN_MOUSE (30-507): 0: 586: 58.80		Q91YX7_MOUSE (72-437): 1.02e-44: 174: 11.58
+	Mm
		639459 LYN_MOUSE (1-509): 0: 585: 62.33		Q91YX7_MOUSE (72-437): 1.02e-44: 174: 11.58
+	Hs
		433734 LYN_HUMAN (1-509): 0: 582: 62.72		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		433814 LYN_HUMAN (1-509): 0: 582: 62.72		RHG21_HUMAN (22-662): 1.96e-43: 172: 13.18
+	Hs
		299230 LYN_HUMAN (1-509): 0: 582: 62.72		FARP2_HUMAN (5-183): 2.45e-30: 130: 21.69