HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: PKHA6 (Q9Y2H5)
Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)
Gene: PLEKHA6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 1048
+	Hs
		411861 LCK_HUMAN (1-509): 0: 661: 100.00		PKHA5_HUMAN (1-1012): 2.52e-108: 365: 29.73
+	Hs
		411764 LCK_HUMAN (1-509): 0: 661: 100.00		PKHA7_HUMAN (1-953): 1.72e-90: 315: 23.76
+	Hs
		411755 LCK_HUMAN (1-509): 0: 661: 100.00		RHG21_HUMAN (2-1037): 1.74e-52: 203: 11.31
+	Hs
		411772 LCK_HUMAN (1-509): 0: 661: 100.00		MPRIP_HUMAN (2-667): 4.03e-48: 188: 13.90
+	Hs
		411591 LCK_HUMAN (1-509): 0: 661: 100.00		RASA1_HUMAN (76-636): 1.95e-46: 183: 12.80
+	Hs
		411856 LCK_HUMAN (1-509): 0: 661: 100.00		PKHA4_HUMAN (7-356): 9.25e-41: 164: 26.52
+	Hs
		411709 LCK_HUMAN (1-509): 0: 661: 100.00		GAB1_HUMAN (57-571): 1.19e-38: 156: 13.15
+	Hs
		442777 HCK_HUMAN (1-509): 0: 602: 65.04		RASA1_HUMAN (76-636): 1.95e-46: 183: 12.80
+	Hs
		442894 HCK_HUMAN (1-509): 0: 602: 65.04		ASAP1_HUMAN (29-792): 6.02e-43: 172: 10.34
+	Mm
		763401 FYN_MOUSE (30-507): 0: 586: 58.80		Q91YX7_MOUSE (76-636): 1.02e-47: 185: 13.14
+	Mm
		639459 LYN_MOUSE (1-509): 0: 585: 62.33		Q91YX7_MOUSE (76-636): 1.02e-47: 185: 13.14
+	Hs
		522768 SRC_HUMAN (20-507): 0: 586: 55.00		RASA1_HUMAN (76-636): 1.95e-46: 183: 12.80
+	Gg
		337667 SRC_CHICK (25-507): 0: 589: 56.79		AFAP1_CHICK (7-681): 3.33e-44: 174: 13.15
+	Hs
		412404 FYN_HUMAN (30-507): 0: 586: 59.01		ASAP1_HUMAN (29-792): 6.02e-43: 172: 10.34
+	Hs
		442825 HCK_HUMAN (1-509): 0: 602: 65.04		GAB1_HUMAN (57-571): 1.19e-38: 156: 13.15
+	Hs
		523197 SRC_HUMAN (20-507): 0: 586: 55.00		ASAP1_HUMAN (29-792): 6.02e-43: 172: 10.34
+	Hs
		412353 FYN_HUMAN (30-507): 0: 586: 59.01		PKHA4_HUMAN (7-356): 9.25e-41: 164: 26.52
+	Hs
		522992 SRC_HUMAN (20-507): 0: 586: 55.00		ACAP1_HUMAN (34-342): 2.76e-39: 158: 15.56
+	Hs
		522965 SRC_HUMAN (20-507): 0: 586: 55.00		GAB1_HUMAN (57-571): 1.19e-38: 156: 13.15
+	Mm
		639464 LYN_MOUSE (1-509): 0: 585: 62.33		GAB2_MOUSE (52-570): 4.39e-38: 154: 13.05