HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: E41L3 (Q9Y2J2)
Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]
Gene: EPB41L3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 1087
+	Hs
		412416 FYN_HUMAN (30-507): 0: 586: 59.01		E41L3_HUMAN (1-1087): 0: 752: 100.00
+	Hs
		523221 SRC_HUMAN (20-507): 0: 586: 55.00		E41L3_HUMAN (1-1087): 0: 752: 100.00
+	Hs
		434091 LYN_HUMAN (1-509): 0: 582: 62.72		E41L3_HUMAN (1-1087): 0: 752: 100.00
+	Hs
		411696 LCK_HUMAN (1-509): 0: 661: 100.00		PTN13_HUMAN (4-988): 4.66e-130: 440: 16.62
+	Hs
		411867 LCK_HUMAN (1-509): 0: 661: 100.00		E41L5_HUMAN (74-826): 2.96e-137: 433: 25.07
+	Hs
		411734 LCK_HUMAN (1-509): 0: 661: 100.00		PTN14_HUMAN (91-1077): 1.78e-119: 398: 15.41
+	Hs
		411904 LCK_HUMAN (1-509): 0: 661: 100.00		FARP1_HUMAN (73-662): 1.4e-114: 381: 28.31
+	Hs
		412035 FYN_HUMAN (30-507): 0: 586: 59.01		PTN4_HUMAN (91-695): 1.96e-140: 448: 29.55
+	Hs
		433729 LYN_HUMAN (1-509): 0: 582: 62.72		PTN13_HUMAN (4-988): 4.66e-130: 440: 16.62
+	Hs
		434020 LYN_HUMAN (1-509): 0: 582: 62.72		E41L5_HUMAN (74-826): 2.96e-137: 433: 25.07
+	Hs
		434004 LYN_HUMAN (1-509): 0: 582: 62.72		E41LB_HUMAN (106-908): 2.69e-128: 415: 20.80
+	Hs
		433778 LYN_HUMAN (1-509): 0: 582: 62.72		PTN14_HUMAN (91-1077): 1.78e-119: 398: 15.41
+	Hs
		523042 SRC_HUMAN (20-507): 0: 586: 55.00		FRMD5_HUMAN (108-582): 2.15e-124: 394: 29.73
+	Hs
		523010 SRC_HUMAN (20-507): 0: 586: 55.00		PTN21_HUMAN (91-1043): 1.1e-117: 393: 18.61
+	Hs
		299230 LYN_HUMAN (1-509): 0: 582: 62.72		FARP2_HUMAN (79-584): 1.98e-118: 392: 30.04
+	Hs
		434097 LYN_HUMAN (1-509): 0: 582: 62.72		FARP1_HUMAN (73-662): 1.4e-114: 381: 28.31
+	Hs
		411855 LCK_HUMAN (1-509): 0: 661: 100.00		E41L1_HUMAN (631-1084): 9.44e-23: 107: 21.33
+	Hs
		204599 LYN_HUMAN (1-509): 0: 582: 62.72		E41L2_HUMAN (583-1087): 1.39e-44: 177: 32.64
+	Hs
		433541 LYN_HUMAN (1-509): 0: 582: 62.72		EPB41_HUMAN (701-1083): 3.49e-41: 166: 33.33
+	Hs
		434008 LYN_HUMAN (1-509): 0: 582: 62.72		E41L1_HUMAN (631-1084): 9.44e-23: 107: 21.33