HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.767

The method score is based on:

Property Details
Experiments 25814554, 10629042, 8900205, 8621719, 7642581, 12231245, 12244174, 9535867, 15208330, 12941616, 9311917, 10829062, 16503409, 15190072, 7782294, 8626543, 15556646, 8995358, 8662998, 17094785 and 1 others

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Identification Methods two hybrid, affinity chromatography technology, pull down, enzymatic study, competition binding, experimental interaction detection, anti bait coimmunoprecipitation, two hybrid array, coimmunoprecipitation
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0016567 - protein ubiquitination
GO:0036120 - cellular response to platelet-derived growth factor stimulus
GO:0045121 - membrane raft
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 537
Hs

1 906
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Last updated: 15 Jul 2024