HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: KHDR1 (Q07666)
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)
Gene: KHDRBS1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.755

Property	Details
Experiments	14647465, 9045636, 22745667, 11960376, 31980649, 16888650, 15190072, unassigned1973, unassigned2173, 22641034, 7516469
Identification Methods	affinity chromatography technology, unspecified method, pull down, enzymatic study, two hybrid fragment pooling approach, anti tag coimmunoprecipitation, coimmunoprecipitation, two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0050852 - T cell receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 537 Hs			1 443
+	Mm
		763394 FYN_MOUSE (1-537): 0: 642: 99.44		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Mm
		403437 SRC_MOUSE (1-537): 0: 599: 68.33		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		522933 SRC_HUMAN (1-537): 0: 598: 68.21		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Mm
		980964 YES_MOUSE (1-537): 0: 584: 71.14		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		433330 YES_HUMAN (1-537): 0: 591: 71.61		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		454827 FGR_HUMAN (1-536): 0: 581: 69.82		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		411689 LCK_HUMAN (40-535): 0: 551: 57.60		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		442815 HCK_HUMAN (1-535): 0: 548: 56.64		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Mm
		639447 LYN_MOUSE (1-535): 0: 535: 53.92		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		433719 LYN_HUMAN (1-535): 0: 535: 54.48		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Mm
		763412 FYN_MOUSE (1-537): 0: 642: 99.44		KHDR2_MOUSE (100-443): 8.36e-126: 370: 61.65
+	Hs
		789110 FRK_HUMAN (77-529): 6.35e-176: 507: 52.26		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		991737 ITK_HUMAN (4-526): 5.88e-165: 483: 31.90		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		986367 BTK_HUMAN (5-531): 1.1e-153: 456: 31.02		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		991758 PTK6_HUMAN (83-529): 4.09e-152: 444: 42.92		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		433822 LYN_HUMAN (1-535): 0: 535: 54.48		KHDR2_HUMAN (99-443): 5.18e-130: 381: 60.62
+	Hs
		1046410 PTK6_HUMAN (83-529): 4.09e-152: 444: 42.92		KHDR2_HUMAN (99-443): 5.18e-130: 381: 60.62
+	Dm
		337713 SRC64_DROME (38-536): 2.25e-175: 507: 49.00		Q9W255_DROME (59-398): 6.04e-96: 295: 32.35
+	Hs
		789069 ABL2_HUMAN (7-537): 2.06e-170: 515: 38.09		SF01_HUMAN (82-301): 6.63e-54: 192: 21.33
+	Hs
		337484 ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56		SF01_HUMAN (82-301): 6.63e-54: 192: 21.33