HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: NMDE1 (Q12879)
Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A)
Gene: GRIN2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	12932824, 9892651, 12419528, 10458595
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0030163 - protein catabolic process GO:0042177 - negative regulation of protein catabolic process GO:0045471 - response to ethanol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 537 Hs			1 1464
+	Hs
		522943 SRC_HUMAN (1-537): 0: 598: 68.21		NMDE1_HUMAN (1-1464): 0: 1763: 100.00
+	Hs
		412171 FYN_HUMAN (1-537): 0: 643: 100.00		NMDE2_HUMAN (4-1464): 0: 1550: 52.95
+	Mm
		403431 SRC_MOUSE (1-537): 0: 599: 68.33		NMDE2_MOUSE (4-1464): 0: 1534: 52.82
+	Hs
		412144 FYN_HUMAN (1-537): 0: 643: 100.00		NMDZ1_HUMAN (8-940): 0: 680: 23.30
+	Rn
		723636 SRC_RAT (1-537): 0: 601: 67.72		NMDZ1_RAT (8-940): 0: 685: 23.30
+	Mm
		403420 SRC_MOUSE (1-537): 0: 599: 68.33		NMDZ1_MOUSE (8-940): 0: 684: 23.20