HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15929943
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0035556 - intracellular signal transduction GO:0050852 - T cell receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 537 Hs			1 533
+	Mm
		763395 FYN_MOUSE (1-537): 0: 642: 99.44		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		522951 SRC_HUMAN (1-537): 0: 598: 68.21		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		411700 LCK_HUMAN (40-535): 0: 551: 57.60		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		442821 HCK_HUMAN (1-535): 0: 548: 56.64		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		433736 LYN_HUMAN (1-535): 0: 535: 54.48		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		763411 FYN_MOUSE (1-537): 0: 642: 99.44		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Hs
		996556 ITK_HUMAN (4-526): 5.88e-165: 483: 31.90		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		523025 SRC_HUMAN (1-537): 0: 598: 68.21		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Mm
		976831 ITK_MOUSE (5-526): 6.73e-164: 480: 32.77		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Mm
		536209 FGR_MOUSE (1-536): 0: 569: 69.15		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Hs
		412433 FYN_HUMAN (1-537): 0: 643: 100.00		MYO16_HUMAN (111-438): 6.65e-11: 67.4: 12.90
+	Mm
		639462 LYN_MOUSE (1-535): 0: 535: 53.92		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Hs
		522749 SRC_HUMAN (1-537): 0: 598: 68.21		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		433917 LYN_HUMAN (1-535): 0: 535: 54.48		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		297808 LYN_HUMAN (1-535): 0: 535: 54.48		K0754_HUMAN (18-469): 5.29e-28: 121: 11.97
+	Hs
		203198 LCK_HUMAN (40-535): 0: 551: 57.60		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		411582 LCK_HUMAN (40-535): 0: 551: 57.60		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Mm
		976834 ITK_MOUSE (5-526): 6.73e-164: 480: 32.77		BLNK_MOUSE (78-520): 1.72e-37: 145: 23.27
+	Hs
		433560 LYN_HUMAN (1-535): 0: 535: 54.48		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		337335 ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92