HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: ABI1 (Q8IZP0)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	20598684
Identification Methods	array technology
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0001764 - neuron migration GO:0005634 - nucleus GO:0005829 - cytosol GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0014069 - postsynaptic density and 1 others more... GO:0048813 - dendrite morphogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 537 Hs			1 508
+	Hs
		523060 SRC_HUMAN (1-537): 0: 598: 68.21		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		433413 YES_HUMAN (1-537): 0: 591: 71.61		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		454841 FGR_HUMAN (1-536): 0: 581: 69.82		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		411788 LCK_HUMAN (40-535): 0: 551: 57.60		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		442853 HCK_HUMAN (1-535): 0: 548: 56.64		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		412404 FYN_HUMAN (1-537): 0: 643: 100.00		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Mm
		763381 FYN_MOUSE (1-537): 0: 642: 99.44		HCLS1_MOUSE (266-503): 2.48e-29: 122: 20.07
+	Hs
		166024 FYN_HUMAN (1-537): 0: 643: 100.00		SYNJ2_HUMAN (39-458): 2.1e-26: 115: 13.88
+	Hs
		522981 SRC_HUMAN (1-537): 0: 598: 68.21		SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72
+	Hs
		523197 SRC_HUMAN (1-537): 0: 598: 68.21		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Hs
		433350 YES_HUMAN (1-537): 0: 591: 71.61		SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72
+	Hs
		412426 FYN_HUMAN (1-537): 0: 643: 100.00		CD2AP_HUMAN (451-508): 2.26e-14: 77.9: 40.68
+	Hs
		433354 YES_HUMAN (1-537): 0: 591: 71.61		LASP1_HUMAN (285-503): 9.91e-33: 127: 19.28
+	Hs
		203198 LCK_HUMAN (40-535): 0: 551: 57.60		SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55
+	Hs
		442894 HCK_HUMAN (1-535): 0: 548: 56.64		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Mm
		411921 LCK_MOUSE (40-535): 0: 553: 57.20		HCLS1_MOUSE (266-503): 2.48e-29: 122: 20.07
+	Hs
		454795 FGR_HUMAN (1-536): 0: 581: 69.82		HCLS1_HUMAN (342-503): 7.7e-19: 91.2: 22.17
+	Mm
		639446 LYN_MOUSE (1-535): 0: 535: 53.92		SRC8_MOUSE (291-502): 1.17e-33: 136: 20.64
+	Mm
		639438 LYN_MOUSE (1-535): 0: 535: 53.92		HCLS1_MOUSE (266-503): 2.48e-29: 122: 20.07
+	Hs
		442898 HCK_HUMAN (1-535): 0: 548: 56.64		CD2AP_HUMAN (451-508): 2.26e-14: 77.9: 40.68