HitPredict

Interactor 1: KIN28 (P06242)
Serine/threonine-protein kinase KIN28 (EC 2.7.11.23)
Gene: KIN28

Interactor 2: SSN8 (P47821)
RNA polymerase II holoenzyme cyclin-like subunit (Suppressor of RNA polymerase B 11)
Gene: SSN8

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.781

Property	Details
Experiments	19450536, 18719252
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 306 Sc			1 323
+	Hs
		538471 CDK2_HUMAN (4-298): 6.96e-156: 439: 39.19		CCNB1_HUMAN (28-316): 1.99e-82: 257: 11.38
+	Hs
		303829 CDK2_HUMAN (4-298): 6.96e-156: 439: 39.19		CCNB2_HUMAN (16-318): 2.18e-80: 251: 14.47
+	Hs
		625350 CDK2_HUMAN (4-298): 6.96e-156: 439: 39.19		CCNA1_HUMAN (26-323): 7.45e-79: 249: 17.28
+	Hs
		590125 CDK2_HUMAN (4-298): 6.96e-156: 439: 39.19		CCNA2_HUMAN (26-310): 6.02e-75: 238: 16.67
+	Hs
		538521 CDK3_HUMAN (4-305): 5.85e-148: 419: 38.94		CCNB1_HUMAN (28-316): 1.99e-82: 257: 11.38
+	Hs
		624422 CDK3_HUMAN (4-305): 5.85e-148: 419: 38.94		CCNC_HUMAN (1-307): 3.27e-79: 244: 28.17
+	Mm
		956332 CDK2_MOUSE (4-298): 1.07e-146: 417: 33.72		CCNC_MOUSE (1-307): 1.82e-79: 245: 28.17
+	Mm
		956329 CDK2_MOUSE (4-298): 1.07e-146: 417: 33.72		CCNA1_MOUSE (20-310): 3.96e-77: 243: 16.67
+	Hs
		590162 CDK3_HUMAN (4-305): 5.85e-148: 419: 38.94		CCNA2_HUMAN (26-310): 6.02e-75: 238: 16.67
+	Mm
		851183 CDK2_MOUSE (4-298): 1.07e-146: 417: 33.72		CCNA2_MOUSE (19-310): 1.88e-75: 239: 17.29
+	Hs
		414711 CDK1_HUMAN (4-293): 1.86e-138: 394: 40.41		CCNB1_HUMAN (28-316): 1.99e-82: 257: 11.38
+	Gg
		533892 CDK1_CHICK (4-305): 1.46e-138: 395: 38.82		CCNB2_CHICK (6-316): 3.99e-82: 255: 15.06
+	Hs
		303821 CDK1_HUMAN (4-293): 1.86e-138: 394: 40.41		CCNB2_HUMAN (16-318): 2.18e-80: 251: 14.47
+	Hs
		414855 CDK1_HUMAN (4-293): 1.86e-138: 394: 40.41		CCNA1_HUMAN (26-323): 7.45e-79: 249: 17.28
+	Xl
		526765 CDK1A_XENLA (4-306): 1.48e-139: 397: 40.33		CCNB1_XENLA (26-315): 1.21e-76: 241: 11.34
+	Hs
		625251 CDK2_HUMAN (4-298): 6.96e-156: 439: 39.19		CCNH_HUMAN (5-298): 1.17e-60: 198: 21.28
+	Hs
		414732 CDK1_HUMAN (4-293): 1.86e-138: 394: 40.41		CCNA2_HUMAN (26-310): 6.02e-75: 238: 16.67
+	Hs
		851197 CDK3_HUMAN (4-305): 5.85e-148: 419: 38.94		CCNH_HUMAN (5-298): 1.17e-60: 198: 21.28
+	Hs
		236679 CDK1_HUMAN (4-293): 1.86e-138: 394: 40.41		CCNT1_HUMAN (46-289): 9.95e-62: 210: 18.43
+	Hs
		960107 CDK3_HUMAN (4-305): 5.85e-148: 419: 38.94		CCNQ_HUMAN (71-297): 8.94e-54: 178: 17.99