HitPredict

Interactor 1: KAPA (P06244)
cAMP-dependent protein kinase type 1 (PKA 1) (EC 2.7.11.11) (CDC25-suppressing protein kinase) (PK-25)
Gene: TPK1

Interactor 2: HSP60 (P19882)
Heat shock protein 60, mitochondrial (CPN60) (P66) (Stimulator factor I 66 kDa component)
Gene: HSP60

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	11805837, 16319894
Identification Methods	anti tag coimmunoprecipitation, enzymatic study
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 397 Sc			1 572
+	Sc
		412940 KAPB_YEAST (68-397): 2.33e-153: 439: 74.85		HSP60_YEAST (1-548): 0: 542: 100.00
+	Dm
		137757 AKT1_DROME (60-397): 4.34e-146: 429: 35.63		CH60A_DROME (1-553): 0: 544: 55.96
+	Mm
		554893 KPCE_MOUSE (7-397): 3.2e-140: 418: 30.77		CH60_MOUSE (4-556): 0: 525: 54.20
+	Hs
		609692 KAPCG_HUMAN (44-397): 1.3e-148: 426: 41.81		TCPH_HUMAN (11-559): 1.16e-177: 514: 18.04
+	Hs
		681999 AKT1_HUMAN (21-392): 1.15e-146: 426: 35.01		TCPH_HUMAN (11-559): 1.16e-177: 514: 18.04
+	Hs
		500182 KS6B2_HUMAN (43-397): 2.4e-140: 410: 36.07		CH60_HUMAN (4-556): 5.37e-180: 521: 54.38
+	Hs
		568585 KAPCA_HUMAN (44-397): 2.33e-150: 430: 44.07		TCPE_HUMAN (1-553): 2.71e-172: 500: 16.84
+	Hs
		609651 KAPCG_HUMAN (44-397): 1.3e-148: 426: 41.81		TCPE_HUMAN (1-553): 2.71e-172: 500: 16.84
+	Hs
		609652 KAPCG_HUMAN (44-397): 1.3e-148: 426: 41.81		TCPG_HUMAN (10-568): 3.04e-172: 500: 14.46
+	Hs
		681735 AKT1_HUMAN (21-392): 1.15e-146: 426: 35.01		TCPE_HUMAN (1-553): 2.71e-172: 500: 16.84
+	Hs
		681738 AKT1_HUMAN (21-392): 1.15e-146: 426: 35.01		TCPG_HUMAN (10-568): 3.04e-172: 500: 14.46
+	Hs
		1306721 KS6B2_HUMAN (43-397): 2.4e-140: 410: 36.07		TCPH_HUMAN (11-559): 1.16e-177: 514: 18.04
+	Hs
		821449 KS6B2_HUMAN (43-397): 2.4e-140: 410: 36.07		TCPE_HUMAN (1-553): 2.71e-172: 500: 16.84
+	Hs
		826928 KS6B2_HUMAN (43-397): 2.4e-140: 410: 36.07		TCPG_HUMAN (10-568): 3.04e-172: 500: 14.46
+	Sc
		520575 YPK1_YEAST (83-374): 2.51e-82: 266: 44.07		HSP60_YEAST (1-548): 0: 542: 100.00
+	Hs
		1306691 SGK2_HUMAN (86-373): 7.93e-81: 254: 42.47		TCPH_HUMAN (11-559): 1.16e-177: 514: 18.04
+	Hs
		821353 SGK3_HUMAN (86-384): 1.29e-79: 254: 41.45		TCPE_HUMAN (1-553): 2.71e-172: 500: 16.84
+	Hs
		821419 SGK2_HUMAN (86-373): 7.93e-81: 254: 42.47		TCPE_HUMAN (1-553): 2.71e-172: 500: 16.84
+	Hs
		826897 SGK2_HUMAN (86-373): 7.93e-81: 254: 42.47		TCPG_HUMAN (10-568): 3.04e-172: 500: 14.46