HitPredict

Interactor 1: GELS (P06396)
Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin)
Gene: GSN

Interactor 2: ACTY (P42025)
Beta-centractin (Actin-related protein 1B) (ARP1B)
Gene: ACTR1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Gelsolin
Common GO terms	GO:0005576 - extracellular region GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0034774 - secretory granule lumen GO:0070062 - extracellular exosome and 1 others more... GO:1904813 - ficolin-1-rich granule lumen
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 782 Hs			1 376
+	Hs
		413876 GELS_HUMAN (1-782): 0: 1207: 100.00		ACTZ_HUMAN (1-376): 0: 728: 90.43
+	Hs
		413874 GELS_HUMAN (1-782): 0: 1207: 100.00		ACTB_HUMAN (8-376): 0: 581: 53.62
+	Hs
		413884 GELS_HUMAN (1-782): 0: 1207: 100.00		ACTG_HUMAN (7-376): 0: 581: 53.74
+	Hs
		413885 GELS_HUMAN (1-782): 0: 1207: 100.00		ACTC_HUMAN (5-376): 0: 577: 53.72
+	Hs
		413881 GELS_HUMAN (1-782): 0: 1207: 100.00		ACTA_HUMAN (5-376): 0: 576: 53.46
+	Hs
		413886 GELS_HUMAN (1-782): 0: 1207: 100.00		ACTS_HUMAN (5-376): 0: 576: 53.19
+	Hs
		785583 SCIN_HUMAN (51-768): 0: 1007: 59.72		ACTY_HUMAN (1-376): 0: 776: 100.00
+	Oc
		101997 G1U9R8_RABIT (44-782): 0: 1156: 94.59		ACTB_RABIT (8-376): 0: 578: 53.35
+	Hs
		892149 SCIN_HUMAN (51-768): 0: 1007: 59.72		ACTB_HUMAN (8-376): 0: 581: 53.62
+	Hs
		930076 SCIN_HUMAN (51-768): 0: 1007: 59.72		ACTG_HUMAN (7-376): 0: 581: 53.74
+	Hs
		932481 SCIN_HUMAN (51-768): 0: 1007: 59.72		ACTC_HUMAN (5-376): 0: 577: 53.72
+	Hs
		915546 SCIN_HUMAN (51-768): 0: 1007: 59.72		ACTA_HUMAN (5-376): 0: 576: 53.46
+	Hs
		933081 SCIN_HUMAN (51-768): 0: 1007: 59.72		ACTS_HUMAN (5-376): 0: 576: 53.19
+	Dm
		501491 QUAI_DROME (41-781): 0: 639: 23.78		ACT1_DROME (7-376): 0: 579: 53.21
+	At
		286684 VILI1_ARATH (56-780): 0: 755: 28.11		ACT12_ARATH (10-376): 5.2e-156: 445: 53.35
+	Hs
		891735 FLII_HUMAN (373-765): 2.36e-57: 214: 22.88		ACTB_HUMAN (8-376): 0: 581: 53.62
+	Hs
		929839 FLII_HUMAN (373-765): 2.36e-57: 214: 22.88		ACTG_HUMAN (7-376): 0: 581: 53.74
+	Hs
		932132 FLII_HUMAN (373-765): 2.36e-57: 214: 22.88		ACTC_HUMAN (5-376): 0: 577: 53.72
+	Dm
		950116 FLII_DROME (399-764): 4.5e-55: 207: 23.90		ACT6_DROME (11-376): 0: 575: 54.87
+	Bt
		221227 SVIL_BOVIN (565-781): 9.32e-25: 113: 23.26		ACTB_BOVIN (8-376): 0: 581: 53.62