HitPredict

Interactor 1: GELS (P06396)
Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin)
Gene: GSN

Interactor 2: TMOD2 (Q9NZR1)
Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)
Gene: TMOD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Gelsolin~Tropomodulin
Common GO terms	GO:0003779 - actin binding GO:0007015 - actin filament organization
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 782 Hs			1 351
+	Hs
		414084 GELS_HUMAN (1-782): 0: 1207: 100.00		TMOD3_HUMAN (1-351): 1.22e-126: 369: 75.85
+	Hs
		413834 GELS_HUMAN (1-782): 0: 1207: 100.00		TMOD1_HUMAN (3-346): 2.23e-115: 340: 59.71
+	Hs
		1349411 SCIN_HUMAN (51-768): 0: 1007: 59.72		TMOD2_HUMAN (1-351): 3.19e-129: 375: 100.00
+	Hs
		1348584 SCIN_HUMAN (51-768): 0: 1007: 59.72		TMOD3_HUMAN (1-351): 1.22e-126: 369: 75.85
+	Hs
		657569 SCIN_HUMAN (51-768): 0: 1007: 59.72		TMOD1_HUMAN (3-346): 2.23e-115: 340: 59.71
+	Hs
		260677 AVIL_HUMAN (68-420): 1.51e-67: 241: 28.29		TMOD2_HUMAN (1-351): 3.19e-129: 375: 100.00
+	Hs
		1023245 FLII_HUMAN (373-765): 2.36e-57: 214: 22.88		TMOD3_HUMAN (1-351): 1.22e-126: 369: 75.85
+	Hs
		657487 FLII_HUMAN (373-765): 2.36e-57: 214: 22.88		TMOD1_HUMAN (3-346): 2.23e-115: 340: 59.71
+	Hs
		1023247 FLII_HUMAN (373-765): 2.36e-57: 214: 22.88		TMOD4_HUMAN (4-345): 1.16e-114: 338: 54.23
+	Hs
		313893 SVIL_HUMAN (551-779): 2.11e-24: 112: 21.86		TMOD3_HUMAN (1-351): 1.22e-126: 369: 75.85
+	Hs
		313758 SVIL_HUMAN (551-779): 2.11e-24: 112: 21.86		TMOD1_HUMAN (3-346): 2.23e-115: 340: 59.71
+	Mm
		1246902 FLII_MOUSE (14-404): 7.21e-29: 126: 20.13		NLRP3_MOUSE (175-335): 1.18e-28: 119: 16.36