HitPredict

Interactor 1: RB (P06400)
Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)
Gene: RB1

Interactor 2: CASP7 (P55210)
Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
Gene: CASP7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	15735701, 11420704
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0051146 - striated muscle cell differentiation GO:0051402 - neuron apoptotic process
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 928 Hs			1 303
+	Hs
		414203 RB_HUMAN (1-928): 0: 1323: 100.00		CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03
+	Hs
		414224 RB_HUMAN (1-928): 0: 1323: 100.00		CASP6_HUMAN (56-301): 5.33e-104: 307: 38.28
+	Hs
		414289 RB_HUMAN (1-928): 0: 1323: 100.00		CASP8_HUMAN (9-301): 8.96e-93: 284: 34.42
+	Hs
		414223 RB_HUMAN (1-928): 0: 1323: 100.00		CASP9_HUMAN (56-301): 2.27e-91: 279: 30.91
+	Hs
		414347 RB_HUMAN (1-928): 0: 1323: 100.00		CASPA_HUMAN (33-251): 4.8e-81: 256: 36.32