HitPredict

Interactor 1: RB (P06400)
Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)
Gene: RB1

Interactor 2: CASP6 (P55212)
Caspase-6 (CASP-6) (CSP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18 (Caspase-6 subunit p20); Caspase-6 subunit p11 (Caspase-6 subunit p10)]
Gene: CASP6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	15735701
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0097284 - hepatocyte apoptotic process
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 928 Hs			1 293
+	Hs
		414222 RB_HUMAN (1-928): 0: 1323: 100.00		CASP7_HUMAN (33-288): 3.89e-113: 330: 38.28
+	Hs
		414203 RB_HUMAN (1-928): 0: 1323: 100.00		CASP3_HUMAN (37-289): 1.09e-110: 323: 41.90
+	Hs
		414289 RB_HUMAN (1-928): 0: 1323: 100.00		CASP8_HUMAN (5-289): 3.37e-98: 298: 30.20
+	Hs
		414223 RB_HUMAN (1-928): 0: 1323: 100.00		CASP9_HUMAN (37-288): 9.05e-97: 292: 29.89
+	Hs
		414347 RB_HUMAN (1-928): 0: 1323: 100.00		CASPA_HUMAN (12-238): 6.22e-75: 239: 32.75