HitPredict

Interactor 1: RB (P06400)
Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)
Gene: RB1

Interactor 2: E2F1 (Q01094)
Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)
Gene: E2F1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.998

The method score is based on:

Property Details
Experiments 19058874, 9501179, 25257171, 28074012, 10891495, 28542143, 21085491, 30867845, 12401786, 8458319, 9219533, 16496386, 31130363, 8230483, 35140242, 16766265, 11839806, 15485920, 22078878, 9553123 and 51 others

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Identification Methods affinity chromatography technology, pull down, proximity labelling technology, x-ray crystallography, two hybrid, anti bait coimmunoprecipitation, experimental interaction detection, comigration in non denaturing gel electrophoresis, coimmunoprecipitation, anti tag coimmunoprecipitation and 1 others

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Interaction Type physical association, direct interaction, association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains E2F_CC-MB~Rb_C
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 7 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 928
Hs

1 437
+ Rn
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Dm
+ At
+ At
+ Dm
+ At
+ Dm
+ Dm
+ Ce
+ Hs
+ Mm

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Last updated: 15 Jul 2024