HitPredict

Interactor 1: RB (P06400)
Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)
Gene: RB1

Interactor 2: E2F4 (Q16254)
Transcription factor E2F4 (E2F-4)
Gene: E2F4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.974

Property	Details
Experiments	9501179, 12401786, 9858615, 10869426, 24981860, 34591612, 8657117, 9380698, 7958924, 34591642, 16360038
Identification Methods	affinity chromatography technology, two hybrid, coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	E2F_CC-MB~Rb_C
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 928 Hs			1 413
+	Mm
		527164 RB_MOUSE (24-928): 0: 1260: 91.38		E2F4_MOUSE (1-413): 4.62e-177: 501: 92.03
+	Hs
		414284 RB_HUMAN (1-928): 0: 1323: 100.00		E2F2_HUMAN (4-252): 2.04e-83: 263: 43.83
+	Hs
		414250 RB_HUMAN (1-928): 0: 1323: 100.00		E2F1_HUMAN (10-278): 8.99e-81: 257: 35.29
+	Hs
		135199 RB_HUMAN (1-928): 0: 1323: 100.00		E2F3_HUMAN (5-289): 3.49e-79: 253: 36.93
+	Hs
		265585 RB_HUMAN (1-928): 0: 1323: 100.00		E2F6_HUMAN (17-244): 1.21e-72: 230: 34.35
+	Mm
		527140 RB_MOUSE (24-928): 0: 1260: 91.38		E2F2_MOUSE (4-244): 2.59e-82: 260: 43.09
+	Mm
		192503 RB_MOUSE (24-928): 0: 1260: 91.38		E2F3_MOUSE (5-255): 3.63e-78: 250: 37.55
+	Rn
		140344 RB_RAT (1-928): 0: 1274: 88.90		E2F1_RAT (10-278): 2.31e-68: 224: 33.95
+	Mm
		527156 RB_MOUSE (24-928): 0: 1260: 91.38		E2F1_MOUSE (10-278): 3.12e-69: 226: 34.19
+	Hs
		414295 RB_HUMAN (1-928): 0: 1323: 100.00		E2F5_HUMAN (304-412): 2.39e-35: 134: 39.34
+	At
		1324895 RBR1_ARATH (19-886): 0: 632: 22.98		E2FA_ARATH (3-298): 3.72e-103: 316: 35.33
+	At
		1325150 RBR1_ARATH (19-886): 0: 632: 22.98		E2FB_ARATH (4-279): 6.71e-80: 255: 33.12
+	Dm
		1097882 RBF_DROME (26-860): 0: 684: 21.83		E2F1_DROME (13-207): 3.06e-55: 196: 38.19
+	At
		1325146 RBR1_ARATH (19-886): 0: 632: 22.98		E2FC_ARATH (1-226): 4.63e-77: 245: 41.30
+	Dm
		284513 RBF_DROME (26-860): 0: 684: 21.83		E2F2_DROME (5-192): 8.58e-52: 179: 31.91
+	Mm
		1145491 RBL1_MOUSE (594-879): 2.53e-78: 278: 29.52		E2F4_MOUSE (1-413): 4.62e-177: 501: 92.03
+	Ce
		106296 LIN35_CAEEL (57-783): 2.49e-125: 404: 19.93		G5EF11_CAEEL (12-215): 2.05e-64: 211: 40.00
+	Dm
		284545 Q9VF04_DROME (51-764): 1.26e-133: 421: 19.00		E2F2_DROME (5-192): 8.58e-52: 179: 31.91
+	Dm
		284539 Q9NIS1_DROME (51-764): 2.83e-133: 420: 19.00		E2F2_DROME (5-192): 8.58e-52: 179: 31.91
+	Hs
		135214 RBL1_HUMAN (598-875): 2.06e-76: 272: 28.92		E2F3_HUMAN (5-289): 3.49e-79: 253: 36.93