HitPredict

Interactor 1: RB (P06400)
Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)
Gene: RB1

Interactor 2: UHRF2 (Q96PU4)
E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2)
Gene: UHRF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	27114453, 21952639
Identification Methods	affinity chromatography technology, far western blotting, pull down, anti tag coimmunoprecipitation, antibody array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0030154 - cell differentiation GO:0051726 - regulation of cell cycle GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 928 Hs			1 802
+	Hs
		414360 RB_HUMAN (1-928): 0: 1323: 100.00		UHRF1_HUMAN (1-802): 0: 817: 53.01
+	Hs
		414392 RB_HUMAN (1-928): 0: 1323: 100.00		KDM5B_HUMAN (251-428): 5.45e-41: 165: 18.09
+	Hs
		414184 RB_HUMAN (1-928): 0: 1323: 100.00		KDM5A_HUMAN (347-404): 1.06e-12: 74.1: 36.21
+	Hs
		660092 RBL1_HUMAN (598-875): 2.06e-76: 272: 28.92		KDM5A_HUMAN (347-404): 1.06e-12: 74.1: 36.21