HitPredict

Interactor 1: PRGR (P06401)
Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)
Gene: PGR

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.585

Property	Details
Experiments	36279628, 33846359
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 933 Hs			1 724
+	Hs
		414416 PRGR_HUMAN (1-933): 3.14e-133: 424: 100.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		437625 MCR_HUMAN (12-933): 3.27e-105: 351: 29.16		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Mm
		415154 GCR_MOUSE (256-933): 1.73e-102: 339: 35.04		HS90B_MOUSE (1-724): 0: 1089: 99.59
+	Hs
		431441 MCR_HUMAN (12-933): 3.27e-105: 351: 29.16		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Mm
		59437 A3KN90_MOUSE (12-933): 3.81e-99: 334: 29.91		HS90B_MOUSE (1-724): 0: 1089: 99.59
+	Hs
		377022 GCR_HUMAN (256-933): 3.11e-99: 330: 33.82		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		437831 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Rn
		415133 GCR_RAT (256-933): 2.07e-97: 325: 34.31		HS90B_RAT (1-724): 0: 1089: 99.59
+	Hs
		377015 GCR_HUMAN (256-933): 3.11e-99: 330: 33.82		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431458 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		320158 ERR2_HUMAN (483-917): 5.66e-97: 313: 24.14		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438124 NR1H3_HUMAN (473-916): 1.45e-95: 310: 20.97		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Rn
		415141 GCR_RAT (256-933): 2.07e-97: 325: 34.31		HS90A_RAT (1-724): 0: 1070: 84.45
+	Hs
		320155 ERR2_HUMAN (483-917): 5.66e-97: 313: 24.14		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431801 NR1H3_HUMAN (473-916): 1.45e-95: 310: 20.97		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		432122 ESR2_HUMAN (453-926): 9.09e-93: 305: 22.80		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		368832 ESR1_HUMAN (398-917): 2.19e-90: 301: 20.82		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		377062 GCR_HUMAN (256-933): 3.11e-99: 330: 33.82		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Hs
		538337 ESR2_HUMAN (453-926): 9.09e-93: 305: 22.80		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Hs
		1123455 ESR2_HUMAN (453-926): 9.09e-93: 305: 22.80		H90B3_HUMAN (1-724): 0: 815: 75.83