HitPredict

Interactor 1: PRGR (P06401)
Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)
Gene: PGR

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	11117529
Identification Methods	biochemical
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding GO:0010629 - negative regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 933 Hs			1 628
+	Hs
		487883 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		1270069 ESR2_HUMAN (453-926): 9.09e-93: 305: 22.80		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		370843 ESR1_HUMAN (398-917): 2.19e-90: 301: 20.82		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		277885 PRGR_HUMAN (1-933): 3.14e-133: 424: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278210 PRGR_HUMAN (1-933): 3.14e-133: 424: 100.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		277876 GCR_HUMAN (256-933): 3.11e-99: 330: 33.82		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277899 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278072 NR1H3_HUMAN (473-916): 1.45e-95: 310: 20.97		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278138 ESR2_HUMAN (453-926): 9.09e-93: 305: 22.80		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277875 ESR1_HUMAN (398-917): 2.19e-90: 301: 20.82		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		277974 HNF4A_HUMAN (567-919): 4.87e-84: 280: 22.60		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278207 GCR_HUMAN (256-933): 3.11e-99: 330: 33.82		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278213 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278312 ESR2_HUMAN (453-926): 9.09e-93: 305: 22.80		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278206 ESR1_HUMAN (398-917): 2.19e-90: 301: 20.82		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		487590 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		510028 ERR1_HUMAN (496-855): 3.68e-96: 311: 27.50		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		782594 HNF4A_HUMAN (567-919): 4.87e-84: 280: 22.60		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		487832 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		ZMIZ1_HUMAN (79-422): 1.82e-84: 287: 24.93
+	Hs
		487597 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		ZMIZ2_HUMAN (81-619): 2.53e-79: 271: 20.46