HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	27402161
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 2 others more... GO:0016020 - membrane GO:0030332 - cyclin binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 609
+	Hs
		523528 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		XRCC6_HUMAN (1-609): 0: 666: 100.00
+	Sp
		293300 CDK1_SCHPO (1-291): 2.43e-132: 378: 63.64		KU70_SCHPO (19-609): 1.01e-168: 495: 27.04
+	Hs
		524796 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77
+	Sc
		565764 PHO85_YEAST (3-295): 4.36e-130: 373: 49.17		KU80_YEAST (36-591): 1.04e-109: 344: 15.33
+	Sp
		383475 CDK1_SCHPO (1-291): 2.43e-132: 378: 63.64		KU80_SCHPO (33-481): 1.97e-83: 277: 15.34