HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: CCNO (P22674)
Cyclin-O
Gene: CCNO

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0009410 - response to xenobiotic stimulus and 1 others more... GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 297 Hs			1 350
+	Hs
		303829 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CCNB2_HUMAN (14-345): 1.8e-102: 308: 21.37
+	Hs
		538471 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CCNB1_HUMAN (2-346): 1.61e-100: 305: 19.39
+	Hs
		625350 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CCNA1_HUMAN (73-345): 7.93e-97: 296: 25.36
+	Hs
		538521 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CCNB1_HUMAN (2-346): 1.61e-100: 305: 19.39
+	Hs
		590125 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CCNA2_HUMAN (2-345): 1.71e-96: 294: 23.92
+	Hs
		303821 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CCNB2_HUMAN (14-345): 1.8e-102: 308: 21.37
+	Hs
		610197 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CCNO_HUMAN (1-350): 2.69e-97: 293: 100.00
+	Hs
		414711 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CCNB1_HUMAN (2-346): 1.61e-100: 305: 19.39
+	Mm
		509465 CDK1_MOUSE (1-297): 4.35e-142: 403: 96.97		CCNB1_MOUSE (2-346): 4.73e-100: 303: 21.56
+	Hs
		590162 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CCNA2_HUMAN (2-345): 1.71e-96: 294: 23.92
+	Hs
		610205 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CCNO_HUMAN (1-350): 2.69e-97: 293: 100.00
+	Hs
		414855 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CCNA1_HUMAN (73-345): 7.93e-97: 296: 25.36
+	Hs
		414732 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CCNA2_HUMAN (2-345): 1.71e-96: 294: 23.92
+	Hs
		331629 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CCNE2_HUMAN (4-289): 4.08e-86: 267: 22.15
+	Hs
		625523 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		Q8WUE3_HUMAN (4-289): 5.25e-86: 266: 22.15
+	Hs
		624539 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CCNE1_HUMAN (15-324): 3.7e-84: 262: 18.50
+	Hs
		331637 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CCNE2_HUMAN (4-289): 4.08e-86: 267: 22.15
+	Hs
		331626 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CCNE2_HUMAN (4-289): 4.08e-86: 267: 22.15
+	Hs
		624573 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CCNE1_HUMAN (15-324): 3.7e-84: 262: 18.50
+	Hs
		414745 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CCNE1_HUMAN (15-324): 3.7e-84: 262: 18.50