HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: CKS2 (P33552)
Cyclin-dependent kinases regulatory subunit 2 (CKS-2)
Gene: CKS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.981

Property	Details
Experiments	25852190, 26186194, 26496610, 1944283, 32707033, 36736316, 35235311, 18471975, 23602568, 28514442, 33961781, 19786724
Identification Methods	affinity chromatography technology, pull down, cross-linking study, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0003682 - chromatin binding GO:0048144 - fibroblast proliferation GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 297 Hs			1 79
+	Hs
		625283 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Hs
		625164 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CKS2_HUMAN (1-79): 8.58e-38: 122: 100.00
+	Hs
		895413 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Hs
		414843 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Hs
		706796 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CKS2_HUMAN (1-79): 8.58e-38: 122: 100.00
+	At
		621728 CDKA1_ARATH (1-290): 1.2e-137: 392: 67.01		CKS2_ARATH (5-78): 2.49e-39: 126: 66.22
+	At
		188136 CDKA1_ARATH (1-290): 1.2e-137: 392: 67.01		CKS1_ARATH (5-73): 5.91e-38: 123: 68.12
+	Dm
		618415 CDK1_DROME (1-290): 2.24e-136: 389: 73.45		Q9VHN1_DROME (1-71): 3.94e-38: 123: 69.01
+	Hs
		895414 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Hs
		706797 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		CKS2_HUMAN (1-79): 8.58e-38: 122: 100.00
+	At
		1321299 CDKD1_ARATH (2-297): 4.98e-131: 379: 47.30		CKS2_ARATH (5-78): 2.49e-39: 126: 66.22
+	Dm
		618387 CDK1_DROME (1-290): 2.24e-136: 389: 73.45		CKS1_DROME (3-72): 1.5e-35: 116: 77.14
+	At
		639376 CKB11_ARATH (1-292): 6.81e-132: 378: 52.12		CKS2_ARATH (5-78): 2.49e-39: 126: 66.22
+	At
		1227962 CKB21_ARATH (1-295): 9.26e-131: 375: 53.14		CKS2_ARATH (5-78): 2.49e-39: 126: 66.22
+	At
		188137 CKB11_ARATH (1-292): 6.81e-132: 378: 52.12		CKS1_ARATH (5-73): 5.91e-38: 123: 68.12
+	At
		1321252 CDKD2_ARATH (1-296): 7.95e-130: 374: 45.61		CKS2_ARATH (5-78): 2.49e-39: 126: 66.22
+	At
		188156 CKB21_ARATH (1-295): 9.26e-131: 375: 53.14		CKS1_ARATH (5-73): 5.91e-38: 123: 68.12
+	At
		188163 CDKD2_ARATH (1-296): 7.95e-130: 374: 45.61		CKS1_ARATH (5-73): 5.91e-38: 123: 68.12
+	At
		188157 CKB22_ARATH (1-295): 4.69e-130: 373: 57.10		CKS1_ARATH (5-73): 5.91e-38: 123: 68.12
+	Sp
		383445 CDK1_SCHPO (1-291): 2.43e-132: 378: 63.64		CKS1_SCHPO (4-78): 2.51e-31: 107: 47.62