HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0010628 - positive regulation of gene expression
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 839
+	Rn
		974740 CDK5_RAT (1-293): 9.73e-134: 382: 56.12		NTRK3_RAT (1-839): 0: 657: 93.17
+	Hs
		384287 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Rn
		974744 CDK5_RAT (1-293): 9.73e-134: 382: 56.12		NTRK2_RAT (6-839): 0: 557: 52.88
+	Mm
		546285 CDK5_MOUSE (1-293): 2.32e-134: 383: 56.12		NTRK2_MOUSE (6-839): 0: 555: 53.29
+	Hs
		609180 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		FGFR3_HUMAN (140-838): 3.83e-170: 514: 23.73
+	Hs
		384094 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		414738 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		FGFR3_HUMAN (140-838): 3.83e-170: 514: 23.73
+	Hs
		507863 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		384655 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		414702 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Rn
		728443 CDK5_RAT (1-293): 9.73e-134: 382: 56.12		NTRK1_RAT (58-839): 1.52e-171: 517: 47.78
+	Hs
		414737 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		507952 CDK16_HUMAN (1-297): 6.03e-124: 364: 51.68		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		411301 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		414872 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		435611 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		414687 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Dm
		337646 CDK1_DROME (1-290): 2.24e-136: 389: 73.45		ABL_DROME (525-833): 3.11e-57: 215: 38.98