HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: SPDYC (Q5MJ68)
Speedy protein C (Rapid inducer of G2/M progression in oocytes C) (RINGO C) (hSpy/Ringo C)
Gene: SPDYC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 15574121
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~Spy1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 274
+	Hs
		625484 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		SPDYC_HUMAN (1-274): 6.78e-180: 497: 100.00
+	Hs
		625485 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		SPDYA_HUMAN (36-233): 1.44e-92: 277: 45.07
+	Xl
		724514 CDK1A_XENLA (1-296): 1.57e-141: 402: 87.50		SPD1A_XENLA (36-219): 3.7e-100: 296: 55.14
+	Xl
		621606 CDK1B_XENLA (1-296): 1.54e-140: 399: 87.16		SPD1A_XENLA (36-219): 3.7e-100: 296: 55.14
+	Hs
		414952 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		SPDYA_HUMAN (36-233): 1.44e-92: 277: 45.07
+	Hs
		960292 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		SPDYA_HUMAN (36-233): 1.44e-92: 277: 45.07
+	Hs
		625476 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		SPDE7_HUMAN (37-168): 5.22e-73: 224: 39.74
+	Hs
		960374 CDK16_HUMAN (1-297): 6.03e-124: 364: 51.68		SPDYA_HUMAN (36-233): 1.44e-92: 277: 45.07
+	Hs
		63992 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		SPDE4_HUMAN (37-170): 1.08e-70: 219: 45.52
+	Hs
		414944 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		SPDE7_HUMAN (37-168): 5.22e-73: 224: 39.74
+	Hs
		64006 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		SPDE4_HUMAN (37-170): 1.08e-70: 219: 45.52
+	Hs
		63987 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		SPDE4_HUMAN (37-170): 1.08e-70: 219: 45.52
+	Hs
		625518 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		SPDE1_HUMAN (37-168): 2.51e-62: 201: 32.04
+	Hs
		414999 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		SPDE1_HUMAN (37-168): 2.51e-62: 201: 32.04
+	Hs
		64007 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		SPDE4_HUMAN (37-170): 1.08e-70: 219: 45.52
+	Hs
		960311 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		SPDE1_HUMAN (37-168): 2.51e-62: 201: 32.04
+	Hs
		64008 CDK16_HUMAN (1-297): 6.03e-124: 364: 51.68		SPDE4_HUMAN (37-170): 1.08e-70: 219: 45.52