HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: CCNQ (Q8N1B3)
Cyclin-Q (CDK10-activating cyclin) (Cyclin-M) (Cyclin-related protein FAM58A)
Gene: CCNQ

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	24218572
Identification Methods	lexa b52 complementation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 297 Hs			1 248
+	Hs
		625350 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CCNA1_HUMAN (1-248): 1.44e-69: 222: 16.87
+	Hs
		538471 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CCNB1_HUMAN (1-242): 2.32e-66: 213: 11.57
+	Hs
		590125 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CCNA2_HUMAN (1-248): 1.38e-64: 208: 15.26
+	Hs
		414855 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CCNA1_HUMAN (1-248): 1.44e-69: 222: 16.87
+	Hs
		303829 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CCNB2_HUMAN (1-243): 4e-63: 204: 11.93
+	Hs
		538521 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CCNB1_HUMAN (1-242): 2.32e-66: 213: 11.57
+	Mm
		956329 CDK2_MOUSE (1-297): 2.06e-140: 401: 55.94		CCNA1_MOUSE (1-248): 2.98e-69: 220: 16.47
+	Hs
		414711 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CCNB1_HUMAN (1-242): 2.32e-66: 213: 11.57
+	Hs
		590162 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CCNA2_HUMAN (1-248): 1.38e-64: 208: 15.26
+	Hs
		236679 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CCNT1_HUMAN (6-243): 2.98e-62: 209: 20.00
+	Hs
		414732 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CCNA2_HUMAN (1-248): 1.38e-64: 208: 15.26
+	Mm
		509465 CDK1_MOUSE (1-297): 4.35e-142: 403: 96.97		CCNB1_MOUSE (1-238): 2.83e-65: 210: 13.03
+	Mm
		509476 CDK1_MOUSE (1-297): 4.35e-142: 403: 96.97		CCNA2_MOUSE (1-248): 2.18e-65: 210: 16.06
+	Mm
		851183 CDK2_MOUSE (1-297): 2.06e-140: 401: 55.94		CCNA2_MOUSE (1-248): 2.18e-65: 210: 16.06
+	Hs
		303821 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CCNB2_HUMAN (1-243): 4e-63: 204: 11.93
+	Hs
		624422 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CCNC_HUMAN (18-245): 2.56e-61: 196: 21.49
+	Hs
		960107 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CCNQ_HUMAN (19-248): 3.96e-62: 196: 100.00
+	Mm
		509487 CDK1_MOUSE (1-297): 4.35e-142: 403: 96.97		CCNC_MOUSE (18-245): 1.95e-61: 196: 21.49
+	Hs
		625251 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CCNH_HUMAN (43-209): 1.31e-22: 95.9: 19.16
+	Hs
		851197 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		CCNH_HUMAN (43-209): 1.31e-22: 95.9: 19.16