HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: TCPH (Q99832)
T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (Chaperonin containing T-complex polypeptide 1 subunit 7) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed]
Gene: CCT7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26496610, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 543
+	Hs
		625579 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		TCPH_HUMAN (1-543): 0: 647: 100.00
+	Hs
		960322 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		TCPH_HUMAN (1-543): 0: 647: 100.00
+	Hs
		625228 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		TCPG_HUMAN (1-541): 0: 577: 31.09
+	Hs
		625220 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		TCPE_HUMAN (3-527): 0: 557: 29.59
+	Hs
		573132 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		TCPA_HUMAN (2-533): 0: 544: 34.54
+	Hs
		414817 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		TCPE_HUMAN (3-527): 0: 557: 29.59
+	Hs
		826623 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		TCPG_HUMAN (1-541): 0: 577: 31.09
+	Sc
		339699 CDK1_YEAST (3-289): 1.25e-128: 369: 60.14		TCPH_YEAST (2-542): 0: 587: 62.45
+	Hs
		414725 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		TCPA_HUMAN (2-533): 0: 544: 34.54
+	Hs
		821173 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		TCPE_HUMAN (3-527): 0: 557: 29.59
+	Hs
		573225 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		TCPA_HUMAN (2-533): 0: 544: 34.54
+	Hs
		625246 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		TCPD_HUMAN (24-520): 4.05e-90: 288: 33.79
+	Hs
		414827 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		TCPD_HUMAN (24-520): 4.05e-90: 288: 33.79
+	Hs
		843162 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		TCPD_HUMAN (24-520): 4.05e-90: 288: 33.79