HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: UBP16 (Q9Y5T5)
Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16)
Gene: USP16

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.655

Property	Details
Experiments	26323689, 10077596, 24013421
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0051301 - cell division
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 823
+	Hs
		414968 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		UBP45_HUMAN (3-823): 2.47e-153: 470: 37.06
+	Hs
		625501 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		UBP37_HUMAN (91-819): 1.96e-79: 277: 14.66
+	Hs
		301349 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		UBP19_HUMAN (611-821): 4.19e-52: 199: 28.64
+	Hs
		415107 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		UBP22_HUMAN (454-823): 6.46e-48: 180: 19.42
+	Dm
		820731 CDK5_DROME (1-289): 4.62e-131: 375: 54.48		UBP2_DROME (627-821): 4.46e-34: 142: 24.12
+	Dm
		820763 CDK5_DROME (1-289): 4.62e-131: 375: 54.48		X2JLM6_DROME (627-821): 1.11e-34: 141: 24.12
+	Dm
		618454 CDK2_DROME (1-290): 5.77e-129: 371: 55.52		UBP2_DROME (627-821): 4.46e-34: 142: 24.12
+	Dm
		618494 CDK2_DROME (1-290): 5.77e-129: 371: 55.52		X2JLM6_DROME (627-821): 1.11e-34: 141: 24.12
+	Hs
		414997 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		UBP32_HUMAN (727-821): 7.28e-16: 84.8: 21.05