Interactor 1: TOP1 (P06612)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme)
Gene: topA

Interactor 2: TOP3 (P14294)
DNA topoisomerase 3 (EC 5.6.2.1) (DNA topoisomerase III)
Gene: topB

Species: Escherichia coli K-12

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 19402753, 15690043
Identification Methods tandem affinity purification, pull down
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Topoisom_bac~Topoisom_bac, Topoisom_bac~Toprim, Toprim~Toprim, Topoisom_bac~zf-C4_Topoisom
Common GO terms GO:0003917 - DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0006265 - DNA topological change
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 865
Ec

1 653
+ Hs

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Last updated: 15 Jul 2024