HitPredict

Interactor 1: DED1 (P06634)
ATP-dependent RNA helicase DED1 (EC 3.6.4.13) (DEAD box protein 1) (Defines essential domain protein 1)
Gene: DED1

Interactor 2: DHH1 (P39517)
ATP-dependent RNA helicase DHH1 (EC 3.6.4.13) (DExD/H-box helicase 1)
Gene: DHH1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	25013175, 18467557, 21712243, 22615397
Identification Methods	affinity chromatography technology, protein complementation assay, dihydrofolate reductase reconstruction
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	DEAD~DEAD, DEAD~Helicase_C, Helicase_C~Helicase_C
Common GO terms	GO:0003724 - RNA helicase activity GO:0003729 - mRNA binding GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0010494 - cytoplasmic stress granule and 1 others more... GO:0016887 - ATP hydrolysis activity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 604 Sc			1 506
+	Hs
		133911 DDX3X_HUMAN (2-604): 2.32e-170: 501: 47.04		IF4A3_HUMAN (10-413): 1.02e-172: 494: 38.42
+	Hs
		133887 DDX3X_HUMAN (2-604): 2.32e-170: 501: 47.04		DDX6_HUMAN (3-421): 1.32e-156: 456: 66.43
+	Hs
		757701 DDX17_HUMAN (72-603): 3.65e-152: 456: 34.92		IF4A3_HUMAN (10-413): 1.02e-172: 494: 38.42
+	Hs
		134146 DDX3X_HUMAN (2-604): 2.32e-170: 501: 47.04		DDX17_HUMAN (1-477): 4.13e-143: 429: 24.85
+	Hs
		133874 DDX3X_HUMAN (2-604): 2.32e-170: 501: 47.04		DDX5_HUMAN (1-417): 2.61e-140: 419: 26.00
+	Dm
		612705 DDX3_DROME (28-532): 6.6e-152: 458: 54.10		DDX6_DROME (15-420): 7.96e-159: 461: 68.97
+	Dm
		612794 Q9W3M7_DROME (46-597): 9.43e-150: 457: 32.21		DDX6_DROME (15-420): 7.96e-159: 461: 68.97
+	Hs
		640569 DDX17_HUMAN (72-603): 3.65e-152: 456: 34.92		DDX6_HUMAN (3-421): 1.32e-156: 456: 66.43
+	Hs
		640533 DDX42_HUMAN (10-602): 6.82e-142: 436: 29.90		DDX6_HUMAN (3-421): 1.32e-156: 456: 66.43
+	Hs
		571538 DDX5_HUMAN (45-602): 9.94e-156: 462: 34.56		DDX17_HUMAN (1-477): 4.13e-143: 429: 24.85
+	Hs
		1271612 DDX17_HUMAN (72-603): 3.65e-152: 456: 34.92		DDX17_HUMAN (1-477): 4.13e-143: 429: 24.85
+	Hs
		571300 DDX5_HUMAN (45-602): 9.94e-156: 462: 34.56		DDX5_HUMAN (1-417): 2.61e-140: 419: 26.00
+	Sc
		624023 DBP2_YEAST (31-600): 1.22e-148: 441: 37.98		DBP2_YEAST (1-415): 1.19e-141: 420: 27.53
+	Dm
		580744 DDX3_DROME (28-532): 6.6e-152: 458: 54.10		DDX17_DROME (1-417): 1.21e-129: 395: 27.51
+	Hs
		133951 DDX3X_HUMAN (2-604): 2.32e-170: 501: 47.04		IF4A1_HUMAN (46-413): 5.64e-89: 280: 44.47
+	Dm
		580714 DDX17_DROME (137-531): 1.86e-98: 317: 43.89		DDX17_DROME (1-417): 1.21e-129: 395: 27.51