HitPredict

Interactor 1: DED1 (P06634)
ATP-dependent RNA helicase DED1 (EC 3.6.4.13) (DEAD box protein 1) (Defines essential domain protein 1)
Gene: DED1

Interactor 2: IF4F2 (P39936)
Eukaryotic initiation factor 4F subunit p130 (eIF-4F p130) (eIF4F p130) (Translation initiation factor 4(4)-F(6) subunit gamma(3) protein 2) (eIF4G2) (mRNA cap-binding protein complex subunit p130)
Gene: TIF4632

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.890

Property	Details
Experiments	25013175, 18467557, 32469309, 22615397
Identification Methods	affinity chromatography technology, protein complementation assay, pull down, dihydrofolate reductase reconstruction
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	DEAD~MIF4G, Helicase_C~MIF4G
Common GO terms	GO:0003729 - mRNA binding GO:0003743 - translation initiation factor activity GO:0006413 - translational initiation GO:0010494 - cytoplasmic stress granule GO:1901195 - positive regulation of formation of translation preinitiation complex
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 604 Sc			1 914
+	Sc
		415980 DED1_YEAST (1-588): 0: 531: 100.00		IF4F1_YEAST (1-914): 1.37e-142: 449: 47.13
+	Hs
		133990 DDX3X_HUMAN (2-604): 2.32e-170: 501: 47.04		IF4G1_HUMAN (19-906): 2.59e-119: 399: 16.78
+	Sc
		624098 DBP2_YEAST (31-600): 1.22e-148: 441: 37.98		IF4F1_YEAST (1-914): 1.37e-142: 449: 47.13
+	Hs
		133973 DDX3X_HUMAN (2-604): 2.32e-170: 501: 47.04		IF4G2_HUMAN (516-898): 3.67e-94: 319: 25.06
+	Hs
		134144 DDX3X_HUMAN (2-604): 2.32e-170: 501: 47.04		CBP_HUMAN (10-391): 2.53e-50: 195: 14.15
+	Hs
		1154061 DDX17_HUMAN (72-603): 3.65e-152: 456: 34.92		NIPBL_HUMAN (34-581): 6.8e-56: 213: 12.86
+	Hs
		134001 DDX3X_HUMAN (2-604): 2.32e-170: 501: 47.04		EP300_HUMAN (8-465): 2.15e-38: 158: 10.92
+	Hs
		571535 DDX5_HUMAN (45-602): 9.94e-156: 462: 34.56		CBP_HUMAN (10-391): 2.53e-50: 195: 14.15
+	Hs
		1270758 DDX17_HUMAN (72-603): 3.65e-152: 456: 34.92		CBP_HUMAN (10-391): 2.53e-50: 195: 14.15
+	Hs
		571417 DDX5_HUMAN (45-602): 9.94e-156: 462: 34.56		EP300_HUMAN (8-465): 2.15e-38: 158: 10.92
+	Hs
		998944 DDX17_HUMAN (72-603): 3.65e-152: 456: 34.92		EP300_HUMAN (8-465): 2.15e-38: 158: 10.92
+	Hs
		998860 DDX42_HUMAN (10-602): 6.82e-142: 436: 29.90		EP300_HUMAN (8-465): 2.15e-38: 158: 10.92