HitPredict - High confidence protein-protein interactions

Interactor 1: SIR2 (P06700)
NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2)
Gene: SIR2

Interactor 2: SIR2 (P06700)
NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2)
Gene: SIR2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	9122169, 27185881, 16543151, 17043313, 21179020
Identification Methods	affinity chromatography technology, x-ray crystallography, pull down, tandem affinity purification
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	DUF592~DUF592, DUF592~SIR2, SIR2~SIR2
Common GO terms	GO:0000183 - rDNA heterochromatin formation GO:0000781 - chromosome, telomeric region GO:0000792 - heterochromatin GO:0003714 - transcription corepressor activity GO:0005634 - nucleus and 26 others more... GO:0005637 - nuclear inner membrane GO:0005654 - nucleoplasm GO:0005677 - chromatin silencing complex GO:0005730 - nucleolus GO:0006303 - double-strand break repair via nonhomologous end joining GO:0006325 - chromatin organization GO:0007062 - sister chromatid cohesion GO:0008156 - negative regulation of DNA replication GO:0016740 - transferase activity GO:0017136 - NAD-dependent histone deacetylase activity GO:0030466 - silent mating-type cassette heterochromatin formation GO:0030869 - RENT complex GO:0031047 - regulatory ncRNA-mediated gene silencing GO:0031507 - heterochromatin formation GO:0031509 - subtelomeric heterochromatin formation GO:0032041 - NAD-dependent histone H3K14 deacetylase activity GO:0033553 - rDNA heterochromatin GO:0034398 - telomere tethering at nuclear periphery GO:0045910 - negative regulation of DNA recombination GO:0046872 - metal ion binding GO:0046969 - NAD-dependent histone H3K9 deacetylase activity GO:0046970 - NAD-dependent histone H4K16 deacetylase activity GO:0070403 - NAD+ binding GO:0097695 - establishment of protein-containing complex localization to telomere GO:0097752 - regulation of DNA stability GO:1904524 - negative regulation of DNA amplification
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1	562
Sc

1	562

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Last updated: 15 Jul 2024