HitPredict

Interactor 1: SIR2 (P06700)
NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2)
Gene: SIR2

Interactor 2: H3 (P61830)
Histone H3
Gene: HHT1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.708

Property	Details
Experiments	19782027, 10693811, 17889663, 19217406, 22474337
Identification Methods	affinity chromatography technology, enzymatic study, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006325 - chromatin organization
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 562 Sc			1 136
+	Hs
		934960 SIR2_HUMAN (217-561): 3.35e-119: 359: 28.57		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		935101 SIR1_HUMAN (202-525): 7.26e-102: 325: 37.76		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		952539 SIR1_HUMAN (202-525): 7.26e-102: 325: 37.76		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Hs
		935287 SIR3_HUMAN (241-545): 2.18e-101: 313: 32.59		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		935278 SIR7_HUMAN (174-535): 1.51e-93: 293: 19.30		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		934984 SIR6_HUMAN (246-529): 2.2e-81: 260: 21.95		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Sc
		864134 HST2_YEAST (256-526): 8.82e-86: 272: 31.03		H3_YEAST (1-136): 1.51e-56: 174: 100.00
+	Hs
		1136676 SIR6_HUMAN (246-529): 2.2e-81: 260: 21.95		H37_HUMAN (1-136): 6.09e-59: 180: 86.77
+	Sc
		864160 HST3_YEAST (240-520): 6.42e-70: 233: 27.19		H3_YEAST (1-136): 1.51e-56: 174: 100.00
+	Hs
		828300 SIR6_HUMAN (246-529): 2.2e-81: 260: 21.95		CENPA_HUMAN (9-133): 2.55e-40: 133: 47.73