HitPredict

Interactor 1: S10A6 (P06703)
Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6)
Gene: S100A6

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	37217945, 20591429
Identification Methods	affinity chromatography technology, pull down, molecular sieving, surface plasmon resonance
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008270 - zinc ion binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 90 Hs			1 491
+	Hs
		962851 HORN_HUMAN (1-86): 3.59e-30: 113: 28.41		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		615210 S10A1_HUMAN (1-88): 9.49e-34: 112: 43.33		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		642935 S10A4_HUMAN (1-90): 7.66e-33: 111: 48.91		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		661229 S10A2_HUMAN (1-90): 1.38e-31: 107: 45.65		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		380767 S100B_HUMAN (3-89): 1.01e-28: 100: 39.33		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		169240 S10A1_HUMAN (1-88): 9.49e-34: 112: 43.33		MDM4_HUMAN (4-489): 0: 531: 32.08
+	Hs
		169242 S10A2_HUMAN (1-90): 1.38e-31: 107: 45.65		MDM4_HUMAN (4-489): 0: 531: 32.08
+	Hs
		169226 S100B_HUMAN (3-89): 1.01e-28: 100: 39.33		MDM4_HUMAN (4-489): 0: 531: 32.08
+	Hs
		169246 S10A5_HUMAN (1-88): 1.41e-25: 92.2: 51.14		MDM4_HUMAN (4-489): 0: 531: 32.08