HitPredict

Interactor 1: IF4E (P06730)
Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)
Gene: EIF4E

Interactor 2: 4EBP1 (Q13541)
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)
Gene: EIF4EBP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 12747804, 17353931, 16242075, 16824195, 10405182, 11605658, 18957614, 33852892, 7935836, 8521827, 16798736, 15767663, 21798997, 22509910, 25416956, 26186194, 16189514, 28514442, 25940091, 24931163 and 36 others

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Identification Methods pull down, affinity chromatography technology, far western blotting, two hybrid, biochemical, isothermal titration calorimetry, anti bait coimmunoprecipitation, nuclear magnetic resonance, anti tag coimmunoprecipitation, classical fluorescence spectroscopy and 10 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains IF4E~eIF_4EBP
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0017148 - negative regulation of translation
and 1 others

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Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 217
Hs

1 118
+ Rn
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Dm
+ Dm
+ Dm
+ Hs
+ Dm
+ Dm

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Last updated: 15 Jul 2024