Interactor 1: DPOLB (P06746)
DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18)
Gene: POLB

Interactor 2: APEX1 (P27695)
DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial]
Gene: APEX1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 0.55 0.620

The method score is based on:

Property Details
Experiments 9207062, 28986522, 17803946
Identification Methods two hybrid, pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0003684 - damaged DNA binding
GO:0003906 - DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 4 others

more...

Homologous interactions 0

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Last updated: 15 Jul 2024