HitPredict

Interactor 1: NPM (P06748)
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Gene: NPM1

Interactor 2: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26186194, 28514442, 33961781, 16522924
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005813 - centrosome GO:0006334 - nucleosome assembly GO:0042393 - histone binding and 1 others more... GO:0090398 - cellular senescence
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 294 Hs			1 143
+	Hs
		418565 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		H2A1A_HUMAN (1-125): 8.26e-67: 200: 92.00
+	Hs
		391502 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70
+	Hs
		418322 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70
+	Hs
		260716 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69
+	Hs
		271252 NPM3_HUMAN (10-119): 6.13e-58: 185: 43.75		H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00
+	Hs
		271355 NPM3_HUMAN (10-119): 6.13e-58: 185: 43.75		H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97
+	Hs
		271251 NPM3_HUMAN (10-119): 6.13e-58: 185: 43.75		H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47