HitPredict

Interactor 1: NPM (P06748)
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Gene: NPM1

Interactor 2: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	25192599, 27460707
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0003713 - transcription coactivator activity GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005737 - cytoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 294 Hs			1 526
+	Hs
		418185 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		418836 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35
+	Hs
		418236 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00
+	Hs
		271309 NPM3_HUMAN (10-119): 6.13e-58: 185: 43.75		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05