HitPredict

Interactor 1: NPM (P06748)
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Gene: NPM1

Interactor 2: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.753

The method score is based on:

Property	Details
Experiments	29283500, 16679321, 15989956, 14636574, 22561347, 20308430, 25600590, 18259216, 24769896, 19901969
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008285 - negative regulation of cell population proliferation and 3 others more... GO:0019901 - protein kinase binding GO:0051059 - NF-kappaB binding GO:0090398 - cellular senescence
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	294
Hs

1	156

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024