HitPredict - High confidence protein-protein interactions

Interactor 1: NPM (P06748)
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Gene: NPM1

Interactor 2: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.661

Property	Details
Experiments	19074833, 21988832, 14743216
Identification Methods	affinity chromatography technology, two hybrid, tandem affinity purification
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 9 others more... GO:0008284 - positive regulation of cell population proliferation GO:0019901 - protein kinase binding GO:0042803 - protein homodimerization activity GO:0043066 - negative regulation of apoptotic process GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051059 - NF-kappaB binding GO:0051092 - positive regulation of NF-kappaB transcription factor activity GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	294
Hs

1	551

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Last updated: 15 Jul 2024