HitPredict

Interactor 1: NPM (P06748)
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Gene: NPM1

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

The method score is based on:

Property	Details
Experiments	29746960, 33742100, 16107701
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 7 others more... GO:0005829 - cytosol GO:0032993 - protein-DNA complex GO:0034644 - cellular response to UV GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051059 - NF-kappaB binding GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	294
Hs

1	2414

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024