HitPredict

Interactor 1: STE7 (P06784)
Serine/threonine-protein kinase STE7 (EC 2.7.12.2)
Gene: STE7

Interactor 2: CDC4 (P07834)
Cell division control protein 4 (E3 ubiquitin ligase complex SCF subunit CDC4) (F-box protein CDC4)
Gene: CDC4

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.50	0.512

Property	Details
Experiments	23645675
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 515 Sc			1 779
+	Hs
		681967 AKT1_HUMAN (74-515): 1.82e-123: 371: 16.56		FBXW7_HUMAN (449-777): 4.6e-67: 237: 21.18
+	Hs
		625543 CDK2_HUMAN (188-474): 2.72e-121: 359: 23.00		FBXW7_HUMAN (449-777): 4.6e-67: 237: 21.18
+	Hs
		160697 AURKA_HUMAN (66-484): 2.87e-113: 342: 21.99		FBXW7_HUMAN (449-777): 4.6e-67: 237: 21.18
+	Hs
		1027412 STK3_HUMAN (167-488): 2.93e-103: 319: 29.94		FBXW7_HUMAN (449-777): 4.6e-67: 237: 21.18
+	Hs
		972235 MP2K1_HUMAN (131-484): 1.92e-95: 296: 33.00		FBXW7_HUMAN (449-777): 4.6e-67: 237: 21.18
+	Hs
		682069 AKT1_HUMAN (74-515): 1.82e-123: 371: 16.56		FZR1_HUMAN (385-680): 3.82e-35: 142: 14.50
+	Hs
		625637 CDK2_HUMAN (188-474): 2.72e-121: 359: 23.00		FZR1_HUMAN (385-680): 3.82e-35: 142: 14.50
+	Hs
		682082 AKT1_HUMAN (74-515): 1.82e-123: 371: 16.56		FBW1A_HUMAN (603-777): 1.43e-28: 123: 13.89
+	Hs
		160853 AURKA_HUMAN (66-484): 2.87e-113: 342: 21.99		FZR1_HUMAN (385-680): 3.82e-35: 142: 14.50
+	Hs
		160864 AURKA_HUMAN (66-484): 2.87e-113: 342: 21.99		FBW1A_HUMAN (603-777): 1.43e-28: 123: 13.89
+	Hs
		1023143 STK4_HUMAN (191-496): 5.71e-104: 321: 30.20		FBW1A_HUMAN (603-777): 1.43e-28: 123: 13.89
+	Hs
		1027457 STK3_HUMAN (167-488): 2.93e-103: 319: 29.94		FBW1A_HUMAN (603-777): 1.43e-28: 123: 13.89
+	Hs
		1023136 STK4_HUMAN (191-496): 5.71e-104: 321: 30.20		FBW1B_HUMAN (603-777): 4.82e-27: 118: 13.89
+	Hs
		1027451 STK3_HUMAN (167-488): 2.93e-103: 319: 29.94		FBW1B_HUMAN (603-777): 4.82e-27: 118: 13.89
+	Hs
		625202 CDK2_HUMAN (188-474): 2.72e-121: 359: 23.00		LIS1_HUMAN (704-777): 3.69e-11: 67.7: 9.21
+	Hs
		972272 MP2K1_HUMAN (131-484): 1.92e-95: 296: 33.00		FBW1A_HUMAN (603-777): 1.43e-28: 123: 13.89
+	Dm
		1249851 HIPPO_DROME (191-493): 9.97e-98: 311: 30.16		FBXW7_DROME (664-777): 1.63e-17: 89.7: 11.30
+	Dm
		1249839 HIPPO_DROME (191-493): 9.97e-98: 311: 30.16		Q9VDE3_DROME (658-777): 3.54e-15: 81.2: 5.56
+	Dm
		1363651 PAK_DROME (74-467): 1.4e-95: 306: 24.63		Q9VDE3_DROME (658-777): 3.54e-15: 81.2: 5.56
+	Hs
		734902 MP2K2_HUMAN (190-486): 1.63e-62: 211: 36.47		WDR5_HUMAN (603-775): 6.17e-29: 120: 19.89