HitPredict

Interactor 1: TOP2 (P06786)
DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
Gene: TOP2

Interactor 2: TOP2 (P06786)
DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
Gene: TOP2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.970

The method score is based on:

Property Details
Experiments 7893659, 9115283, 6088500, 7935413, 18097402, 10201398, 20485342, 23022727, 8538787
Identification Methods pull down, biochemical, x-ray crystallography, molecular sieving
Interaction Type direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains DNA_gyraseB~DNA_gyraseB, DNA_gyraseB~DNA_topoisoIV, DNA_gyraseB~HATPase_c, DNA_gyraseB~Toprim, DNA_topoisoIV~DNA_topoisoIV, DNA_topoisoIV~Toprim, DNA_topoisoIV~TOPRIM_C, HATPase_c~HATPase_c, Toprim~Toprim, TOPRIM_C~Toprim
Common GO terms GO:0000019 - regulation of mitotic recombination
GO:0000712 - resolution of meiotic recombination intermediates
GO:0000795 - synaptonemal complex
GO:0000819 - sister chromatid segregation
GO:0003677 - DNA binding
and 13 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 1428
Sc

1 1428
+ Hs
+ Hs
+ Zm
+ Dm
+ Ec
+ At
+ Mp
+ Sp
+ Mp
+ Ec
+ Mp
+ Ec
+ Ec
+ Ec
+ Ec
+ Hp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024