HitPredict

Interactor 1: TOP2 (P06786)
DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
Gene: TOP2

Interactor 2: SSB1 (P11484)
Ribosome-associated molecular chaperone SSB1 (EC 3.6.4.10) (Cold-inducible protein YG101) (Heat shock protein SSB1) (Hsp70 chaperone Ssb)
Gene: SSB1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	19536198, 16429126
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1428 Sc			1 613
+	Sc
		420130 TOP2_YEAST (1-1428): 0: 1426: 100.00		SSB2_YEAST (1-613): 0: 1118: 99.35
+	Hs
		503324 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		HSP7C_HUMAN (5-612): 0: 900: 59.84
+	Sc
		513077 MDN1_YEAST (838-1427): 3.39e-52: 205: 10.77		SSB1_YEAST (1-613): 0: 1128: 100.00
+	Sc
		510394 USO1_YEAST (873-1423): 3.54e-33: 142: 10.02		SSB1_YEAST (1-613): 0: 1128: 100.00
+	Sc
		630960 USO1_YEAST (873-1423): 3.54e-33: 142: 10.02		SSB2_YEAST (1-613): 0: 1118: 99.35