HitPredict

Interactor 1: TOP2 (P06786)
DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
Gene: TOP2

Interactor 2: H3 (P61830)
Histone H3
Gene: HHT1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	37968396, 22199229
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0006325 - chromatin organization GO:0009303 - rRNA transcription
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1428 Sc			1 136
+	Hs
		508935 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		508945 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Hs
		509016 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Hs
		934678 TOP2B_HUMAN (2-1420): 0: 1475: 40.55		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		952283 TOP2B_HUMAN (2-1420): 0: 1475: 40.55		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Hs
		973351 TOP2B_HUMAN (2-1420): 0: 1475: 40.55		H3C_HUMAN (1-136): 8.2e-59: 179: 86.03
+	Hs
		508870 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		CENPA_HUMAN (9-133): 2.55e-40: 133: 47.73
+	Hs
		828199 TOP2B_HUMAN (2-1420): 0: 1475: 40.55		CENPA_HUMAN (9-133): 2.55e-40: 133: 47.73
+	Sc
		420113 TOP2_YEAST (1-1428): 0: 1426: 100.00		CENPA_YEAST (24-134): 7.32e-41: 137: 53.04