HitPredict

Interactor 1: TOP2 (P06786)
DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
Gene: TOP2

Interactor 2: RSC2 (Q06488)
Chromatin structure-remodeling complex subunit RSC2 (RSC complex subunit RSC2) (Remodel the structure of chromatin complex subunit 2)
Gene: RSC2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	37968396
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1428 Sc			1 889
+	Hs
		509005 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		BRD3_HUMAN (7-385): 2.06e-68: 243: 15.92
+	Hs
		973337 TOP2B_HUMAN (2-1420): 0: 1475: 40.55		BRD3_HUMAN (7-385): 2.06e-68: 243: 15.92
+	Hs
		508967 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		EP300_HUMAN (4-191): 1.16e-32: 139: 18.75
+	Mm
		964603 TOP2A_MOUSE (3-1427): 0: 1488: 40.97		SMCA4_MOUSE (9-122): 2.28e-30: 131: 30.17
+	Hs
		973319 TOP2B_HUMAN (2-1420): 0: 1475: 40.55		EP300_HUMAN (4-191): 1.16e-32: 139: 18.75
+	Hs
		508826 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		BRD2_HUMAN (2-255): 2.31e-29: 127: 15.89
+	Hs
		508882 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		SMCA4_HUMAN (9-122): 8.4e-29: 126: 29.92
+	Hs
		631406 TOP2B_HUMAN (2-1420): 0: 1475: 40.55		BRD2_HUMAN (2-255): 2.31e-29: 127: 15.89
+	Hs
		243848 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		BRD4_HUMAN (2-329): 9.37e-27: 120: 12.65
+	Hs
		244311 TOP2B_HUMAN (2-1420): 0: 1475: 40.55		BRD4_HUMAN (2-329): 9.37e-27: 120: 12.65
+	Mm
		964613 TOP2A_MOUSE (3-1427): 0: 1488: 40.97		PB1_MOUSE (3-125): 2.9e-19: 95.9: 20.64
+	Hs
		509044 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		PB1_HUMAN (234-742): 1.78e-19: 96.7: 14.64
+	Hs
		170230 TOP2A_HUMAN (2-1427): 0: 1480: 41.18		TIF1A_HUMAN (47-132): 1.21e-11: 71: 32.22
+	Sc
		420112 TOP2_YEAST (1-1428): 0: 1426: 100.00		BDF1_YEAST (26-219): 5.23e-19: 94.4: 12.63
+	Sc
		420101 TOP2_YEAST (1-1428): 0: 1426: 100.00		STH1_YEAST (275-377): 2.49e-11: 69.8: 24.27
+	Sc
		420157 TOP2_YEAST (1-1428): 0: 1426: 100.00		RSC4_YEAST (34-128): 1.91e-10: 66.7: 27.84
+	Sc
		728775 MDN1_YEAST (838-1427): 3.39e-52: 205: 10.77		BDF1_YEAST (26-219): 5.23e-19: 94.4: 12.63
+	Hs
		631467 CAPR2_HUMAN (905-1423): 9.32e-40: 163: 12.10		BRD2_HUMAN (2-255): 2.31e-29: 127: 15.89