HitPredict

Interactor 1: TNFA (P06804)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: Tnf

Interactor 2: TF65 (Q04207)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: Rela

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 0.60 0.757

The method score is based on:

Property Details
Experiments 19285436, 19662631, 17785847, 16413922, 20221401, 20534538, 21098092, 21131967, 20685965, 21725320, 21825016, 22388040, 25548221, 25690886
Identification Methods anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0006952 - defense response
GO:0006954 - inflammatory response
GO:0008284 - positive regulation of cell population proliferation
GO:0009410 - response to xenobiotic stimulus
and 17 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 235
Mm

1 549
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024