HitPredict

Interactor 1: KLK1 (P06870)
Kallikrein-1 (EC 3.4.21.35) (Kidney/pancreas/salivary gland kallikrein) (Tissue kallikrein)
Gene: KLK1

Interactor 2: KAIN (P29622)
Kallistatin (Kallikrein inhibitor) (Peptidase inhibitor 4) (PI-4) (Serpin A4)
Gene: SERPINA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10862973
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 262 Hs			1 427
+	Hs
		344148 KLK1_HUMAN (1-262): 8.56e-125: 357: 100.00		A1AT_HUMAN (4-426): 9.9e-166: 473: 42.55
+	Hs
		344274 KLK2_HUMAN (1-261): 6.63e-115: 331: 65.90		AACT_HUMAN (19-426): 5.72e-168: 479: 44.25
+	Hs
		344349 KLK13_HUMAN (1-260): 9.68e-106: 309: 40.07		AACT_HUMAN (19-426): 5.72e-168: 479: 44.25
+	Hs
		344149 KLK3_HUMAN (1-261): 6.64e-108: 314: 60.54		A1AT_HUMAN (4-426): 9.9e-166: 473: 42.55
+	Mm
		430527 Q9Z1R9_MOUSE (5-261): 3.31e-115: 332: 40.86		A1AT1_MOUSE (30-425): 4.52e-156: 448: 43.07
+	Hs
		344097 KLK1_HUMAN (1-262): 8.56e-125: 357: 100.00		ANT3_HUMAN (25-424): 5.82e-143: 417: 31.14
+	Hs
		397636 KLK2_HUMAN (1-261): 6.63e-115: 331: 65.90		IPSP_HUMAN (37-424): 4.27e-154: 443: 45.62
+	Hs
		397629 KLK3_HUMAN (1-261): 6.64e-108: 314: 60.54		IPSP_HUMAN (37-424): 4.27e-154: 443: 45.62
+	Hs
		428671 TRY1_HUMAN (5-262): 3.83e-115: 332: 40.31		SPB8_HUMAN (51-424): 1.07e-145: 421: 30.79
+	Hs
		589593 KLK2_HUMAN (1-261): 6.63e-115: 331: 65.90		SPB6_HUMAN (51-424): 6.47e-144: 416: 30.79
+	Hs
		719387 KLK13_HUMAN (1-260): 9.68e-106: 309: 40.07		SPB6_HUMAN (51-424): 6.47e-144: 416: 30.79
+	Mm
		1141519 KLK8_MOUSE (2-260): 5.89e-102: 299: 42.86		SPB6_MOUSE (51-424): 6.96e-146: 421: 31.84
+	Hs
		371463 KLKB1_HUMAN (17-261): 4.48e-88: 275: 31.92		IPSP_HUMAN (37-424): 4.27e-154: 443: 45.62
+	Hs
		714770 TRY3_HUMAN (11-262): 5.74e-110: 320: 41.67		SPB12_HUMAN (50-424): 2.07e-134: 393: 30.71
+	Hs
		344256 KLK4_HUMAN (23-258): 1.09e-50: 168: 40.08		A1AT_HUMAN (4-426): 9.9e-166: 473: 42.55
+	Hs
		198328 KLK10_HUMAN (28-261): 4.36e-46: 157: 37.29		A1AT_HUMAN (4-426): 9.9e-166: 473: 42.55
+	Hs
		198377 KLK10_HUMAN (28-261): 4.36e-46: 157: 37.29		CBG_HUMAN (45-424): 8.76e-147: 425: 44.47
+	Hs
		198417 KLK10_HUMAN (28-261): 4.36e-46: 157: 37.29		SPB10_HUMAN (50-424): 3.54e-147: 425: 29.07
+	Hs
		344100 GRAA_HUMAN (24-258): 3.08e-37: 133: 35.92		ANT3_HUMAN (25-424): 5.82e-143: 417: 31.14
+	Hs
		198373 KLK10_HUMAN (28-261): 4.36e-46: 157: 37.29		HEP2_HUMAN (32-426): 1.17e-42: 158: 29.14