HitPredict

Interactor 1: ODP2 (P06959)
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (E2)
Gene: aceF

Interactor 2: DLDH (P0A9P0)
Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) (Glycine cleavage system L protein)
Gene: lpdA

Species: Escherichia coli K-12

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.864

The method score is based on:

Property Details
Experiments 16606699, 24561554, 16858726
Identification Methods affinity chromatography technology, two hybrid, blue native page, pull down, two hybrid array
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains E3_binding~Pyr_redox_2, E3_binding~Pyr_redox_dim
Common GO terms GO:0005737 - cytoplasm
GO:0006090 - pyruvate metabolic process
GO:0042867 - pyruvate catabolic process
GO:0045254 - pyruvate dehydrogenase complex
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 630
Ec

1 474
+ At
+ Hs
+ Hs
+ Hs
+ Gs
+ Hs
+ Dm
+ Sc
+ Ec
+ Ss
+ Sc
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024