Interactor 1: NFL (P07196)
Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)
Gene: NEFL

Interactor 2: VIME (P08670)
Vimentin
Gene: VIM

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.971

The method score is based on:

Property Details
Experiments 28514442, 27173435, 34079125, 33961781, 35271311, 34349018, 37071682, 15383276
Identification Methods affinity chromatography technology, proximity labelling technology, cross-linking study, two hybrid, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Filament~Filament
Common GO terms GO:0005200 - structural constituent of cytoskeleton
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005882 - intermediate filament
GO:0019904 - protein domain specific binding
and 2 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 543
Hs

1 466
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Bt
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024