HitPredict

Interactor 1: NFL (P07196)
Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)
Gene: NEFL

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030424 - axon GO:0030426 - growth cone
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 543 Hs			1 2527
+	Hs
		409102 K2C8_HUMAN (69-431): 4.2e-132: 394: 36.44		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130283 K2C73_HUMAN (3-405): 5.47e-88: 283: 30.81		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130818 V9HWE1_HUMAN (34-402): 6.74e-84: 270: 49.59		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		443567 VIME_HUMAN (34-402): 6.74e-84: 270: 49.59		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		61511 A5YM63_HUMAN (82-409): 9.33e-72: 247: 54.71		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		531584 K2C5_HUMAN (56-403): 3.13e-64: 221: 31.62		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		380486 K2C6B_HUMAN (56-419): 8.8e-64: 220: 30.79		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		3119 A0A0S2Z428_HUMAN (56-419): 5.65e-62: 215: 31.06		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		72923 B4DN72_HUMAN (238-543): 5.19e-09: 60.7: 13.29		LRRK2_HUMAN (1-2527): 0: 3008: 99.72